RAF Typhoon FGR4s have conducted a mission with France's air force in a combined operation against an underground arms cache in Syria operated by the Daesh militant organization, according to the British defence ministry.
The site, identified by surveillance, was assessed as housing weapons and explosive materials, the release indicated, and was positioned in mountains just above the historic site of Palmyra in the heart of Syria.
"The RAF jets employed laser-guided Paveway IV weapons to hit a several entry passages providing entry to the site... initial indications are that the strike was effective," the MoD said.
There was no sign of any harm to civilians in the strike on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
IS - referred to as ISIS - imposed jihadist rule over large swathes of both Syria and Iraq until 2019.
"This strike shows British leadership, and determination to work closely with allied nations, to eliminate any revival of the terrorist group and their harmful and extremist ideologies in the Middle East," the British Defence Secretary John Healey remarked.
British military aircraft have performed surveillance missions over Syria to "deter any efforts to regroup" of IS subsequent to its defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank the personnel of British forces participating in this strike for their professionalism and their courage," Healey added. "They were among numerous British personnel deployed over the holidays. This mission, to remove militants who endanger our security, demonstrates how UK forces are ready to step up, continuously, protecting the UK at home and influential overseas."
During December, the American forces executed what it described as a "massive strike" against IS targets in Syria, after an attack resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The U.N. says Daesh still boasts between 5,000 and 7,000 militants in Syria and Iraq.